منابع مشابه
Unraveling the pharmacokinetic interaction of ticagrelor and MEDI2452 (Ticagrelor antidote) by mathematical modeling
The investigational ticagrelor-neutralizing antibody fragment, MEDI2452, is developed to rapidly and specifically reverse the antiplatelet effects of ticagrelor. However, the dynamic interaction of ticagrelor, the ticagrelor active metabolite (TAM), and MEDI2452, makes pharmacokinetic (PK) analysis nontrivial and mathematical modeling becomes essential to unravel the complex behavior of this sy...
متن کاملA specific antidote for dabigatran: functional and structural characterization.
Dabigatran etexilate is a direct thrombin inhibitor and used widely as an anticoagulant for the prevention of stroke in patients with atrial fibrillation. However, anticoagulation therapy can be associated with an increased risk of bleeding. Here, we present data on the identification, humanization, and in vitro pharmacology of an antidote for dabigatran (aDabi-Fab). The X-ray crystal structure...
متن کاملA PoTENtial Antidote
The direct oral anticoagulants (DOACs), which include dabigatran, rivaroxaban, apixaban, and edoxaban, can be given in fixed doses without routine coagulation monitoring. In clinical trials, the DOACs have been shown to be at least as effective as vitamin K antagonists (VKAs), such as warfarin, for stroke prevention in nonvalvular atrial fibrillation and for treatment of venous thromboembolism,...
متن کاملPlenary Paper THROMBOSIS AND HEMOSTASIS A specific antidote for dabigatran: functional and structural characterization
Thromboembolic disorders such as myocardial infarction, stroke, and venous thromboembolism are the most common causes of mortality and morbidity in Western societies. These thromboembolic events can be triggered by excessive activation of coagulation, and thrombin plays a major role in these processes. The most widely used agents for antithrombotic therapy are indirect thrombin inhibitors (such...
متن کاملHumor: an antidote for stress.
Humor and laughter can be effective self-care tools to cope with stress. An ability to find humor gives us a sense of perspective on our problems. Laughter provides a physical release for accumulated tension. The article reviews research on the effect of humor and laughter on our immune function and resilience to stress. Resources for finding humor are included.
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2015
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(15)60253-4